Lähin skitsofreniasimulaattori-päihde?

[Dexma]

. Tästähän maalaisjärkeen syyllistymällä päättelisi että skitsofreniassa aivojen pinta-ala kasvaa.

Kysymyksessä on fyysinen eroavaisuus...

[Happotatti]

http://en.wikipedia.org/wiki/Adrenochrome tuossa.

[dredi]

http://en.wikipedia.org/wiki/Adrenochrome tuossa.

Kais tiiät ettei tuo aine oikeasti ole lainkaan sellaista mitä siinä eräässä leffassa väitettiin?
Itseasiassa ko. aine ei ole edes psykoaktiivinen.

[Happotatti]

Kuulemma aiheuttaa kemiallisen skitsofrenian ja shulgin on puhunut tästä muistaakseni. Ja tästä oli joku analogi joka on myös psykoaktiivinen.

[dredi]

Missä Shulgin on puhunut ja mitä sanonut?
Mikä analogi?

[Nappi-Nalle]

Omasta kokemuksesta sanoisin, että CH3CH2OH.
Delirium on mielenkiintonen.. Ja perseestä, sikäli kun jälkeenpäin mitään muistaa. Mut "ihmisten ilmoille" ei kannata lähtee, se on ku vetäis dexmit sienitripillä keskel rion karnevaalii.

[Happotatti]

Joo, otin selvää. Kun alunperin mutu-tuntumalta postailin.

Adrenochrome semicarbazone olis se väitetysti psykoaktiivinen analogi. ja

From Alexander & Ann Shulgin's PiHKAL (1991), #157 - EXTENSIONS AND COMMENTARY of TMA:

...there had been interest in reports that adrenalin that had become old and discolored seemed to elicit central effects in man. The oxidation products were identified as the deeply colored indolic compound adrenochrome and the colorless analogue adrenolutin. The controversy that these reports created just sort of died away, and the adrenochrome family has never been accepted as being psychedelic. No one in the scientific community today is looking in and about the area, and at present this is considered as an interesting historical footnote.

tuossa shulgin kertoo adrenochromesta.

Eli ei ole todistettu vielä mitään. ennenkuin adrenochrome monosemicarbazonea tai adrenochrome semicarbazonea joku testaa ja kertoo että pärähtikö?

[Happotatti]

In Diet & Neurotoxins, by Gabriel Cousens, MD (2000):

Connection To Schizophrenia
For example, two of these metabolic neurotoxins--adrenolutin and adrenochrome--breakdown products from the body's own epinephrine. Both are associated with biochemically based schizophrenia. Adrenochrome is a hallucinogen which also inhibits nerve cell transmission. If the body is making an excess of adrenochrome, from either stress or a poor biochemical ability to break it down into harmless by-products, we have the potential for brain dysfunction. A slowly emerging awareness from the scientific literature suggests there are a number of brain disturbances that are related to the accumulation of various neurotoxins in the brain.

Entry in Adam Gottlieb's Legal Highs (1973):

ADRENOCHROME SEMICARBAZONE -- 3-hydroxy-1-methyl-5,6-indolinedione semicarbazone.
Material: Oxidized epinephrine (adrenaline) with semicarbazide.
Usage: 100 mg is thoroughly dissolved in just enough alcohol, melted fat (butter), or vegetable oil and ingested. Because of its poor solubility in water these must be used to aid absorption.
Effects: Physical stimulating, feeling of well-being, slight reduction of thought processes.
Contraindications: None noted.
Acts as a systemic hemostatic preventing capillary bleeding during injury. Adrenochrome causes chemically induced schizophrenia. Its semicarbazone does not.

[dredi]

Olisikohan se Erowidissa kun oli ainakin joskus "trippiraportti" adrenokromista. Koitan kaivaa jos löytyis...

My experimentations with Adrenochrome:

I had acquired D,L-Adrenochrome freebase (the one sold at 70euros for 250mg)

first trial: I held 100mg under my tongue for 1 minute and then swallowed. Fast onset (about 5 minutes)

second trial: I snorted 50mg. Onset: a few seconds.

third trial : I smoked 25mg (vaporised in a crack pipe). Onset is almost instant.

Note that I waited a few days between each trial.

The three trials gave me the exact same effects, which were very light and really uninteresting (I wouldn't even call it a high).

First, it's wasn't hallucinogen nor psychedelic. I had a feeling of warmth through my body, I felt a numbness in my hands and my head (possibly linked to the haemostatic effect), there was some slight sedation, and a very slight short lived euphoria (the euphoria was a slightly more pronouced when smoked, but still very short lived)
There's also some minor visual change (no visuals, just that I would see the room slightly differently than usual, but honestly that was some really minor change, a joint of hashish would have done the same, nothing really noticeable). There might be some slight myosis too (=little pupils), not really sure.

To sum up, effects were extremely weak, absolutely not fun nor psychedelic in anyway, and short lived (I would say the slight initial euphoria is gone within 4-5 minutes, and the few strange feelings that I experience from the stuff are gone within about 1 hour (I couldn't say the exact duration as I didn't really checked my watch)
Needless to say I was very disappointed by this uninteresting compound.

The effects I had from it were flimsy, there was a definite effect on my vision and my mental state for sure but I would definitely not call it 'hallucinogenic'.

http://www.erowid.org/experiences/exp.php?ID=51847

Jännä juttu muuten sinänsä ettei adrenokromi sisällä varsinaisesti lainkaan kromia...