Propofol is a water-immiscible oil and so cannot be injected per se. Initial clinical trials were in 1977, in a form solubilised in cremophor EL, but due to anaphylactic reactions it was withdrawn from the market. It was subsequently reformulated as an emulsion of a soya oil/propofol mixture in water, and re-launched in 1986 by AstraZeneca with the brand name Diprivan (Shortened version of DI-isoPRopyl IV ANesthetic). The current preparation is 1% propofol, 10% soybean oil and 1.2% purified egg phospholipid (emulsifier), with 2.25% of glycerol as a tonicity adjusting agent, and sodium hydroxide to adjust the pH. Diprivan contains EDTA as an antimicrobial agent. Newer generic formulations contain sodium metabisulfite or benzyl alcohol. Propofol emulsion appears as a highly opaque white fluid due to the scattering of light from the tiny (~150 nm) oil droplets that it contains.
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Recent research has also suggested the endocannabinoid system may contribute significantly to Propofol's anesthetic action and to its unique properties.[1]
Uuh soijaöljyä suoraan suoneen.. Ja vielä kannabinoidi. Tästäköhän ne valistajat on keksineet sen "kannabistöötistä se narkomaanin ura urkenee"...
The propofol felt like a really good, clean sedative-hypnotic. It was kind of like GHB except that it didn't make me horny. It makes you sleepy, but you can still respond to spoken commands while you are under its influence. Also, I think it causes amnesia. It lasts a short time, about one hour, and is very pleasant.
- cattleprodder @ https://rikki.fi/tajkor/the_best_of_the ... elated.rar
If the falling tide can turn and then recover, all alone we must be part of one another
Onkos muut päässeet propofolia testaamaan ? Itse aika paljon sitä testailin IV:nä keväällä/kesällä. Ei mitenkään ihmeellinen aine, mutta notkuilla sai.
I haven't been this scared since Mother Teresa OD'd in my car
Heh. Veli mäjähti lasisen pöydän läpi heti kun oli saanut painettua männän pohjaan. Istui sohavalla vähän kumarassa eteenpäin ja tyrkkäs, niin suoraa eteenpäin ja pää meni ensimmäisenä pöydän läpi. Eikä edes herännyt. . Tämä on erittäin hyvä unilääke tarvitseville.
e: Polttaa muutes helvetisti suonissa, vaikka sisältää ampulli aina lidokaiinia(puudutusaine).
I haven't been this scared since Mother Teresa OD'd in my car
Ja vielä kannabinoidi. Tästäköhän ne valistajat on keksineet sen "kannabistöötistä se narkomaanin ura urkenee"...
. Tämä on erittäin hyvä unilääke tarvitseville.